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Alli Weight-Loss Pill: Does it Work?

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Miles Becker

By Miles Becker

April 18, 2025


Alli, an over-the-counter weight-loss medication, is designed to help overweight adults, specifically those with a BMI of 25 or more, in their weight-loss journey. This 60-milligram version of orlistat complements a low-calorie, low-fat diet and regular exercise. FDA-approved, it differs from Xenical, the prescription counterpart at 120 milligrams, suitable for individuals with a BMI over 30. Despite its promise, Alli offers modest weight loss, about 5% of body weight, accompanied by side effects such as stomach pain, oily stools, and possible nutrient absorption reduction. Those considering Alli should consult healthcare providers to discuss potential benefits, risks, and personal health conditions.


Safety reviews by FDA have highlighted concerns about possible liver injury, common to orlistat users. Therefore, any symptoms such as itching, jaundice, or appetite loss should prompt immediate medical consultation. To maximize its efficacy, Alli is to be taken thrice daily within an hour of meals containing fat, with the manufacturer's guideline suggesting a daily fat intake limit. Taking multivitamins at different times helps counteract nutrient absorption issues. Continual weight-loss success with Alli relies on consistent adherence to dietary and exercise routines. However, if no significant weight loss is observed within a few months, discontinuing might be wiser to avoid costs and side effects.



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Miles Becker

Miles Becker

Miles Becker is a health science communicator known for his deep dives into anti-aging research, cellular health, and metabolic function. With a PhD in molecular biology, he contributes to The Longevity Edit, Age Well Journal, and BioScience Today.


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