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Understanding Alli: The FDA-Approved Weight Loss Aid

Understanding Alli: The FDA-Approved Weight Loss Aid
Leo Barnes

By Leo Barnes

April 22, 2025


What is Alli?

Alli is a renowned over-the-counter (OTC) weight loss aid that has gained the distinction of being the only product in its category approved by the FDA. Recognized as the #1 doctor-recommended OTC weight loss aid, Alli has become a preferred option for those seeking assistance in their weight loss journey.


Available in various pack sizes, including a 60-count Starter Pack, a 120-count Refill Pack, and a 170-count Pack, Alli offers flexibility in its application. Each 60-count box includes a pill counter designed to aid you in monitoring your progress and maintaining your course towards achieving your weight loss goals.


Usage and Dosage

Alli is designed for overweight adults with a body mass index (BMI) of 25 kg/m² or higher. It is intended to be used in conjunction with a reduced-calorie, low-fat diet for optimal results. Before using Alli, it is essential to consult with a healthcare professional, particularly if there are any questions or concerns regarding its use.


For optimal results, take 1 capsule with each meal containing fat, ensuring not to exceed 3 capsules per day. Additionally, users should incorporate a multivitamin containing fat-soluble vitamins such as vitamins A, D, E, and K, along with beta-carotene, preferably at bedtime, as Alli may affect the absorption of these nutrients.


Mechanism of Action

The active ingredient in Alli is Orlistat 60 mg, which functions primarily as a weight loss aid. Alli works by inhibiting the absorption of some dietary fats, leading them to be expelled from the body instead. This unique action makes it imperative for users to adhere to a low-fat diet to minimize potential gastrointestinal (GI) side effects.


Possible Side Effects

While taking Alli, some users might experience side effects, primarily related to dietary habits and fat intake. Commonly noted side effects are gastrointestinal in nature, including bowel-related changes. These side effects are most prevalent when first starting Alli, as the body adjusts to the reduced-fat diet and the medication itself. Over time, with proper use and diet adjustment, these side effects typically subside.


Importantly, a significant percentage of users who adhere to a low-fat diet while using Alli have reported staying committed to their diet plans for over three months, demonstrating the aid's effectiveness in fostering dietary adherence.


Recommended Diet for Alli Users

For optimal results and the minimization of side effects, it is recommended to preemptively begin a well-balanced, reduced-calorie, low-fat diet before initiating Alli. Consuming about 15 grams of fat per meal can significantly reduce the likelihood of bowel-related changes commonly experienced during Alli therapy.


Users are advised to consume three well-balanced meals and one snack per day. A comprehensive companion guide is available for more in-depth information, assisting users in creating an effective and sustainable meal plan.


Achieving and Maintaining Weight Loss

Once users achieve a BMI of 25 kg/m² or less, Alli's effectiveness decreases, and continued use may not contribute further to weight loss. At this stage, users can cease taking the medication but are encouraged to maintain their weight through lifestyle changes consisting of a balanced diet and regular exercise.


If at any time the user's BMI returns to 25 kg/m² or higher, they can consider resuming Alli to help manage their weight.


Saving with Alli

To help consumers affordably manage their weight, Alli offers promotional savings such as $5 off on a 60-count Starter Pack and $10 off on a 120-count Refill Pack. Additional savings can be accessed via the Haleon Huddle, which provides exclusive deals on a range of brands including Alli.


All trademarks are owned by or licensed to the Haleon group of companies. This site is intended for U.S. residents. For more information, please visit our and terms of use.



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Leo Barnes

Leo Barnes

Leo Barnes is a Toronto-based health editor focused on clean living, immunity, and daily performance. With a degree in nutritional biochemistry, he writes for publications including The Clean Slate, Wellness Radar, and Peak Life Journal.


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