Alli: Everything You Need to Know

Alli (orlistat) is a popular over-the-counter medication designed to aid weight loss for overweight adults aged 18 and older who are committed to following a reduced-calorie, low-fat diet. Its active ingredient, orlistat, is available in a higher dosage by prescription, marketed under the brand name Xenical, which is also prescribed post-weight loss surgery.

How Does Alli Work?

Alli belongs to a category of drugs known as lipase inhibitors. It functions by inhibiting the absorption of approximately 25% of dietary fat in the intestines. This unabsorbed fat is excreted from the body via bowel movements. Research indicates that Alli may also help reduce visceral fat—a risky type of belly fat associated with serious health conditions like type 2 diabetes, high blood pressure, heart disease, and stroke.

Is Alli Right for Me?

For those struggling with weight management where diet and exercise alone have proven ineffective, Alli may be an option. However, it is crucial to continue maintaining a healthy lifestyle, which includes proper diet and regular physical activity. Consider calculating your body mass index (BMI) to assess whether you are in the healthy weight range before consulting with a healthcare provider.

How Do I Take Alli?

Alli capsules are administered orally three times a day with meals containing some fat, or up to one hour post-meal. If a meal contains no fat, your doctor might advise skipping the dose. Adhering to a low-fat, low-calorie diet is vital to minimize digestive side effects. It is also important to supplement with a daily multivitamin containing vitamins A, D, E, K, and beta-carotene since Alli can reduce their absorption.

When Shouldn’t I Take Alli?

Interactions with certain medications can occur; therefore, it is essential to inform your healthcare provider about all drugs you are taking. Avoid Alli in the following cases: organ transplant history, consumption of cyclosporine, pregnancy or breastfeeding, or if you are underweight. Potential side effects include loose stools and other bowel-related changes. If severe symptoms persist, contact your doctor. In rare cases, Alli has been linked to extreme liver injury.

Emergency Side Effects of Alli

Contact emergency services immediately if experiencing difficulty breathing, difficulty swallowing, or show signs of liver damage such as dark urine or jaundice. Although these reactions are rare, they require immediate medical attention.

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